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Common Terminology Criteria for Adverse Events (CTCAE) is widely accepted throughout the oncology community as the standard classification and severity grading scale for adverse events in cancer therapy clinical trials and other oncology settings. The National Cancer Institute issued the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 on May 29, 2009.

Minor editorial updates have been made to CTCAE v4.0, which are represented in v4.03.  These edits do not change the meaning of v4.0 content and all previous versions (CTCAE v4.0, v4.01, v4.02) are still valid and referred to as CTCAE v4.0.  V4.03 includes clarifications for a select few grading scales and adverse event term definitions.  Most of the revisions are associated with grading scales that include a quantitative component.  A list of changes is located at

An updated version (4.03) is now in use as of June 14, 2010. The ManageCRC Advisory Panel will reference CTCAE v 4.03 for future references to adverse event grading with the exception of dose modifications that are based on earlier versions. Information cited in ManageCRC webpages will reference the CTCAE version used as a reference.

Information on the prior and current versions, dictionary of terms and cross reference between versions can be found on the Cancer Therapy Evaluation Program (CTEP) website at  Accessed August 6, 2010.

PDF of CTCAE v 4.03 can be downloaded without charge at  Accessed August 6, 2010.